No association between atonic asthma and a coding variant of FcεR1β in a Japanese population

被引：16

作者：

Ishizawa, M

Shibasaki, M

Yokouchi, Y

Noguchi, E

Arinami, T ^{[1
]}

Yamakawa-Kobayashi, K

Matsui, A

Hamaguchi, H

机构：

[1] Univ Tsukuba, Inst Basic Med Sci, Dept Med Genet, Tsukuba, Ibaraki 3058575, Japan

[2] Univ Tsukuba, Inst Clin Med, Dept Pediat, Tsukuba, Ibaraki 3058575, Japan

来源：

JOURNAL OF HUMAN GENETICS | 1999年 / 44卷 / 05期

关键词：

atopic asthma; IgE receptor; polymorphism; association; transmission disequilibrium test;

D O I：

10.1007/s100380050166

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Susceptibility to atopic diseases is known to involve genetic factors. The Gly237 allele of a polymorphism (Glu237Gly) of the Fc epsilon R1 beta gene is reportedly associated with atopic asthma in Japanese. To confirm this association, we conducted transmission disequilibrium tests in 76 families identified through atopic asthmatics. A case-control study was also carried out in atopic asthmatic subjects and non-atopic controls. The Gly237 allele was not preferentially transmitted to atopic asthma-affected offspring. Neither the Gly237 allele nor the Gly237/Gly237 + Glu237/Gly237 genotypes were significantly more prevalent in the atopic asthmatics than in the controls. This study failed to confirm a substantial role of the Gly237Glu polymorphism of the Fc epsilon R1 beta gene in the genetic predisposition for atopic asthma in this Japanese population.

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页码：308 / 311

页数：4

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