Glucocorticoid receptor β:: View Ii

被引:23
作者
Carlstedt-Duke, J [1 ]
机构
[1] Huddinge Hosp, Karolinska Inst, Dept Med Nutr, Novum, S-14186 Huddinge, Sweden
关键词
D O I
10.1016/S1043-2760(99)00178-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There is a clear role for mechanisms that modulate glucocorticoid receptor (GR) function. The non-steroid-binding GR beta isoform has been proposed to play a role in this modulation but the published data are contradictory. The relative levels of this isoform appear to be low. Alternative mechanisms for the modulation of glucocorticoid action are described and contrasted with the proposed role for GR beta.
引用
收藏
页码:339 / 342
页数:4
相关论文
共 26 条
[1]   Regulation of the human interleukin-2 gene by the α and β isoforms of the glucocorticoid receptor [J].
Bamberger, CM ;
Else, T ;
Bamberger, AM ;
Beil, FU ;
Schulte, HM .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1997, 136 (01) :23-28
[2]   GLUCOCORTICOID RECEPTOR-BETA, A POTENTIAL ENDOGENOUS INHIBITOR OF GLUCOCORTICOID ACTION IN HUMANS [J].
BAMBERGER, CM ;
BAMBERGER, AM ;
DECASTRO, M ;
CHROUSOS, GP .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (06) :2435-2441
[3]   Inhibition of mineralocorticoid activity by the beta-isoform of the human glucocorticoid receptor [J].
Bamberger, CM ;
Bamberger, AM ;
Wald, M ;
Chrousos, GP ;
Schulte, HM .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1997, 60 (1-2) :43-50
[4]   Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction [J].
Bertilsson, G ;
Heidrich, J ;
Svensson, K ;
Åsman, M ;
Jendeberg, L ;
Sydow-Bäckman, M ;
Ohlsson, R ;
Postlind, H ;
Blomquist, P ;
Berkenstam, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12208-12213
[5]   SXR, a novel steroid and xenobiotic-sensing nuclear receptor [J].
Blumberg, B ;
Sabbagh, W ;
Juguilon, H ;
Bolado, J ;
van Meter, CM ;
Ono, ES ;
Evans, RM .
GENES & DEVELOPMENT, 1998, 12 (20) :3195-3205
[6]   NEGATIVE CROSS-TALK BETWEEN RELA AND THE GLUCOCORTICOID RECEPTOR - A POSSIBLE MECHANISM FOR THE ANTIINFLAMMATORY ACTION OF GLUCOCORTICOIDS [J].
CALDENHOVEN, E ;
LIDEN, J ;
WISSINK, S ;
VANDESTOLPE, A ;
RAAIJMAKERS, J ;
KOENDERMAN, L ;
OKRET, S ;
GUSTAFSSON, JA ;
VANDERSAAG, PT .
MOLECULAR ENDOCRINOLOGY, 1995, 9 (04) :401-412
[7]   Expression of glucocorticoid receptor gene isoforms in corticotropin-secreting tumors [J].
Dahia, PLM ;
Honegger, J ;
Reincke, M ;
Jacobs, RA ;
Mirtella, A ;
Fahlbusch, R ;
Besser, GM ;
Chew, SL ;
Grossman, AB .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (04) :1088-1093
[8]   The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): Tissue levels, mechanism of action, and potential physiologic role [J].
deCastro, M ;
Elliot, S ;
Kino, T ;
Bamberger, C ;
Karl, M ;
Webster, E ;
Chrousos, GP .
MOLECULAR MEDICINE, 1996, 2 (05) :597-607
[9]   11 beta-hydroxysteroid dehydrogenases: Key enzymes in determining tissue-specific glucocorticoid effects [J].
Edwards, CRW ;
Benediktsson, R ;
Lindsay, RS ;
Seckl, JR .
STEROIDS, 1996, 61 (04) :263-269
[10]   MINERALOCORTICOID ACTION - TARGET TISSUE-SPECIFICITY IS ENZYME, NOT RECEPTOR, MEDIATED [J].
FUNDER, JW ;
PEARCE, PT ;
SMITH, R ;
SMITH, AI .
SCIENCE, 1988, 242 (4878) :583-585