Successful related umbilical cord blood transplantation for graft failure following T cell-depleted non-identical bone marrow transplantation in a child with major histocompatibility complex class II deficiency

被引：19

作者：

Bonduel, M

del Pozo, A

Zelazko, M

Raslawski, E

Delfino, S

Rossi, J

Figueroa, C

Muriel, FS

机构：

[1] Hosp Pediat Prof Dr Juan P Garrahan, Dept Hematol Oncol, RA-1245 Buenos Aires, DF, Argentina

[2] Hosp Pediat Prof Dr Juan P Garrahan, Bone Marrow Transplant Unit, Buenos Aires, DF, Argentina

[3] Hosp Pediat Prof Dr Juan P Garrahan, Transfus Med Serv, Buenos Aires, DF, Argentina

[4] Hosp Pediat Prof Dr Juan P Garrahan, Dept Immunol, Buenos Aires, DF, Argentina

[5] Hosp Pediat Prof Dr Juan P Garrahan, Dept Radiotherapy, Buenos Aires, DF, Argentina

来源：

BONE MARROW TRANSPLANTATION | 1999年 / 24卷 / 04期

关键词：

SCID; cord blood transplantation; T cell-depleted BMT;

D O I：

10.1038/sj.bmt.1701915

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Major histocompatibility complex (MHC) class II deficiency is a rare form of primary combined immunodeficiency that can only be corrected by stem cell transplantation. We report a 4 1/2-year-old girl with MHC class Il deficiency who underwent a related CBT due to graft failure following T cell-depleted non-identical BRIT. The patient is alive and well 2 years after the second transplant. A sustained hematopoietic engraftment and a progressive immune recovery have been detected. We conclude that cord blood may be an effective source of hematopoietic stem cells for patients with immunodeficiency disorders including diseases with a high rate of graft failure.

引用

页码：437 / 440

页数：4

共 10 条

[1] SUCCESSFUL TREATMENT WITH AN UNRELATED-DONOR BONE-MARROW TRANSPLANT IN AN HLA-DEFICIENT PATIENT WITH SEVERE COMBINED IMMUNE-DEFICIENCY (BARE LYMPHOCYTE SYNDROME) [J].