DNA microarrays in clinical oncology

被引：244

作者：

Ramaswamy, S

Golub, TR

机构：

[1] Harvard Univ, Dana Farber Canc Inst, Sch Med, Dept Adult Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Dana Farber Canc Inst, Sch Med, Dept Pediat Oncol, Boston, MA 02115 USA

[3] MIT, Ctr Genome Res, Whitehead Inst, Cambridge, MA 02139 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2002年 / 20卷 / 07期

关键词：

D O I：

10.1200/JCO.2002.20.7.1932

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aberrant gene expression is critical for tumor initiation and progression. However, we lack a comprehensive understanding of all genes that are aberrantly expressed in human cancer. Recently, DNA microarrays have been used to obtain global views of human cancer gene expression and to identify genetic markers that might be important for diagnosis and therapy. We review clinical applications of these novel tools, discuss some important recent studies, identify promising avenues of research in this emerging field of study, and discuss the likely impact that expression profiling will have on clinical oncology.

引用

页码：1932 / 1941

页数：10

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