Folic acid supplementation of pregnant mice suppresses heat-induced neural tube defects in the offspring

被引:45
作者
Shin, JH
Shiota, K [1 ]
机构
[1] Kyoto Univ, Fac Med, Dept Anat & Dev Biol, Kyoto 6068501, Japan
[2] Kyoto Univ, Fac Med, Congenital Anomaty Res Ctr, Kyoto 6068501, Japan
[3] Korea Food & Drug Adm, Natl Inst Toxicol Res, Seoul 122704, South Korea
关键词
folic acid; myo-inositol; hyperthermia; neural tube defects; pregnancy; mice;
D O I
10.1093/jn/129.11.2070
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Neural tube defects (NTD) are a group of malformations that result from the failure of the neural tube to close early in embryonic development and among the mast common congenital malformations in humans. It has been reported that a substantial proportion of NTD in humans can be prevented by folic acid (FA) supplementation prior to conception and during the first months of pregnancy, and myo-inositol (MI) was shown to reduce the incidence of NTD in curly tail mice which are not prevented by FA. Brief maternal hyperthermia (HT) early in pregnancy has been implicated in NTD both in humans and laboratory animals, and anterior NTD including exencephaly and anencephaly are induced frequently when pregnant mice are exposed to HT. We examined the effect of FA or MI supplementation of pregnant mice on the occurrence of heat-induced NTD in the offspring. When pregnant mice were treated with FA (3 mg/kg) daily from gestational day (GD) 0.5 through GD 9.5 and heated at GD 8.5, the prevalence of NTD in the fetuses (26.6%) was significantly lower than the corresponding figure in the HT alone group (38.6%; P < 0.05). However we failed to detect the preventive effect of MI (500 mg/kg). The results of this study suggest that prenatal FA supplementation decreases MT-induced NTD in mice and sufficient FA intake during early pregnancy may be recommended to avoid the birth of malformed children.
引用
收藏
页码:2070 / 2073
页数:4
相关论文
共 27 条
[1]  
[Anonymous], EPIDEMIOLOGY ANENCEP
[2]  
Atlanta G., 1993, JAMA, V269, P1233, DOI DOI 10.1001/JAMA.1993.03500100029008
[3]  
BARANOV VS, 1966, B EXP BIOL MED, V1, P77
[4]  
*CDC, 1993, JAMA-J AM MED ASSOC, V269, P1238
[5]  
*CDC, 1993, JAMA-J AM MED ASSOC, V269, P1236
[6]   PREVENTION OF THE 1ST OCCURRENCE OF NEURAL-TUBE DEFECTS BY PERICONCEPTIONAL VITAMIN SUPPLEMENTATION [J].
CZEIZEL, AE ;
DUDAS, I .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (26) :1832-1835
[7]   HYPERTHERMIA AND BIRTH-DEFECTS [J].
EDWARDS, MJ ;
SHIOTA, K ;
SMITH, MSR ;
WALSH, DA .
REPRODUCTIVE TOXICOLOGY, 1995, 9 (05) :411-425
[8]   EFFECTS OF LEAD AND HYPERTHERMIA ON PRENATAL BRAIN GROWTH OF GUINEA-PIGS [J].
EDWARDS, MJ ;
BEATSON, J .
TERATOLOGY, 1984, 30 (03) :413-421
[9]  
FERM VH, 1979, BIOL NEONATE, V36, P168, DOI 10.1159/000241223
[10]   Inositol prevents folate-resistant neural tube defects in the mouse [J].
Greene, NDE ;
Copp, AJ .
NATURE MEDICINE, 1997, 3 (01) :60-66