Chemistry of Verongida sponges.: 9.: Secondary metabolite composition of the Caribbean sponge Aplysina cauliformis

被引：36

作者：

Ciminiello, P

Dell'Aversano, C

Fattorusso, E

Magno, S

Pansini, M

机构：

[1] Univ Naples, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Univ Genoa, Ist Zool, I-16126 Genoa, Italy

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 04期

关键词：

D O I：

10.1021/np9805138

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A detailed analysis of the secondary metabolites of the sponge Aplysina cauliformis has been performed. Eight compounds were identified, two of which (13 and 14) are new bromotyrosine derivatives whose structures were determinated from spectroscopic evidence, including 2D NMR. The new compounds were analyzed for cytotoxic activity, and compound 14 was shown to inhibit mammalian protein synthesis and cell proliferation.

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页码：590 / 593

页数：4

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