Nefazodone in post-traumatic stress disorder: results from six open-label trials

被引:56
作者
Hidalgo, R
Hertzberg, MA
Mellman, T
Petty, F
Tucker, P
Weisler, R
Zisook, S
Chen, S
Churchill, E
Davidson, J
机构
[1] Duke Univ, Med Ctr, Durham, NC 27706 USA
[2] Vet Adm Med Ctr, Durham, NC USA
[3] Univ Miami, Vet Adm Med Ctr, Coral Gables, FL 33124 USA
[4] Univ Texas, SW Med Ctr, Dallas, TX USA
[5] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA
[6] Vet Adm Med Ctr, San Diego, CA 92161 USA
[7] Bristol Myers Squibb, Princeton, NJ USA
关键词
nefazodone; response; predictor; post-traumatic stress disorder;
D O I
10.1097/00004850-199903000-00001
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Nefazodone, an antidepressant which blocks serotonin (5-HT)(2) receptors and 5-HT reuptake, was evaluated in the treatment of post-traumatic stress disorder (PTSD) in six open-label studies involving both civilians and combat veterans. Our objective was to report this available pooled data to characterize the response of this drug in PTSD. Specifically, we looked at response rates using three different criteria, the effect of nefazodone on each PTSD cluster and individual symptoms and, lastly, variables that might predict response. One hundred and five outpatients with chronic PTSD were treated with nefazodone titrated up to 600 mg/day, 92 of whom were entered in an intent to treat analysis. We used the percentage drop in score between baseline and endpoint on main scale as a common measure to evaluate outcome. The response criterion of a drop in score of at least 30%, 40% and 50% revealed response rates of 46, 36 and 26%, respectively. Nefazodone showed a broad spectrum of action on PTSD symptoms. This profile might make nefazodone a useful drug to treat PTSD. Predictors of response include age, sex and trauma type. Double blind, placebo-controlled clinical trials in PTSD are in progress to assess the utility of nefazodone as a treatment in this disorder. Int clin Psychopharmacol 14:61-68 (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:61 / 68
页数:8
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