Dynamic transition in tRNA is solvent induced

被引：97

作者：

Caliskan, G

Briber, RM

Thirumalai, D

Garcia-Sakai, V

Woodson, SA

Sokolov, AP ^{[1
]}

机构：

[1] Univ Akron, Dept Polymer Sci, Akron, OH 44325 USA

[2] Johns Hopkins Univ, Dept Biophys, Baltimore, MD 21218 USA

[3] Univ Maryland, Dept Mat Sci & Engn, IPST, College Pk, MD 20472 USA

[4] NIST, Ctr Neutron Res, Gaithersburg, MD 20899 USA

[5] Univ Maryland, Biophys Program, IPST, College Pk, MD USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 01期

关键词：

D O I：

10.1021/ja056444i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dynamics of tRNA was studied using neutron scattering spectroscopy. Despite vast differences in the architecture and backbone structure of proteins and RNA, hydrated tRNA undergoes the dynamic transition at the same temperature as hydrated lysozyme. The similarity of the dynamic transition in RNA and proteins supports the idea that it is solvent induced. Because tRNA essentially has no methyl groups, the results also suggest that methyl groups are not the main contributor of the dynamic transition in biological macromolecules. However, they may explain strong differences in the dynamics of tRNA and lysozyme observed at low temperatures. Copyright © 2006 American Chemical Society.

引用

页码：32 / 33

页数：2

共 22 条

[1] Harmonic behavior of trehalose-coated carbon-monoxy-myoglobin at high temperature [J].