The ''cyclic'' regimen of low-dose doxycycline for adult periodontitis: A preliminary study

被引:77
作者
Crout, RJ
Lee, HM
Schroeder, K
Crout, H
Ramamurthy, NS
Wiener, M
Golub, LM
机构
[1] SUNY STONY BROOK,SCH DENT MED,DEPT ORAL BIOL & PATHOL,STONY BROOK,NY 11794
[2] W VIRGINIA UNIV,DEPT PERIODONTOL,MORGANTOWN,WV 26506
[3] SUNY STONY BROOK,DEPT PERIODONT,STONY BROOK,NY 11794
关键词
doxycycline; gingival crevicular fluid; periodontitis/diagnosis; collagenases; proteinase inhibitors; periodontal attachment; double-blind studies;
D O I
10.1902/jop.1996.67.5.506
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
SPECIALLY-FORMULATED LOW-DOSE DOXYCYCLINE (LDD) regimens have been found to reduce collagenase activity in the gingival tissues and crevicular fluid (GCF) of adult periodontitis subjects in short-term studies. In the current, double-blind, placebo-controlled study, adult periodontitis patients were administered for 6 months a ''cyclical'' regimen of either LDD or placebo capsules; and various clinical parameters of periodontal disease severity, and both collagenase activity and degradation of the serum protein, alpha(1)-PI, in the GCF were measured at different time periods. No significant differences between the LDD- and placebo-treated groups were observed for plaque index and gingival index. However, attachment levels, probing depth, and GCF collagenase activity and alpha(1)-PI degradation were all beneficially and significantly (P < 0.05) affected by the drug regimen. We propose: 1) that LDD inhibits tissue destruction in the absence of either antimicrobial or significant anti-inflammatory efficacy; and 2) that long-term LDD could be a useful adjunct to instrumentation therapy in the management of the adult periodontitis patient.
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页码:506 / 514
页数:9
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