The 1858T PTPN22 gene variant contributes to a genetic risk of type 1 diabetes in a Ukrainian population

被引：34

作者：

Fedetz, M

Matesanz, F

Caro-Maldonado, A

Smirnov, II

Chvorostinka, VN

Moiseenko, TA

Alcina, A

机构：

[1] CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada 18100, Spain

[2] Kharkov Reg Hosp, Dept Endocrinol, Kharkov, Ukraine

[3] Kharkov State Med Acad, Dept Internal Dis, Kharkov, Ukraine

来源：

TISSUE ANTIGENS | 2006年 / 67卷 / 05期

关键词：

ethnic; gene polymorphism; PTPN22; RFLP; type; 1; diabetes; Ukraine;

D O I：

10.1111/j.1399-0039.2006.00591.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The 1858T variant of the protein tyrosine phosphatase gene, PTPN22, is associated with an increased risk of several autoimmune diseases. The aim of this study has been to investigate the possible association of 1858C -> T PTPN22 polymorphism and type 1 diabetes (T1D) in Caucasians from Ukraine. Overall, the distribution of 1858 PTPN22 genotypes differed significantly between the T1D patient group (n = 296) and the control group (n = 242) (P = 0.0036). When both groups were classified according to sex, the TT genotype and T allele showed a statistically significant higher frequency in T1D female patients (5.9 and 22.8%, respectively) in comparison with the female controls (0 and 11.9%) (P = 0.008 for both analyses). The patients with the TT genotype were significantly younger at the onset of T1D compared with those with genotypes TC and CC (P = 0.035 and 0.019, respectively). In our Ukrainian Caucasian cohort, we confirmed the association between T1D and the PTPN22,1858T allele.

引用

页码：430 / 433

页数：4

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