Olanzapine and fluperlapine mimic clozapine in preventing MK-801 neurotoxicity

被引：81

作者：

Farber, NB

Foster, J

Duhan, NL

Olney, JW

机构：

[1] Department of Psychiatry, Washington Univ. School of Medicine, St. Louis, MO 63110

来源：

SCHIZOPHRENIA RESEARCH | 1996年 / 21卷 / 01期

关键词：

novel antipsychotics; blozapine; olanzapine; neurotoxicity; MK-801; phencyclidine; NMDA antagonists; schizophrenia;

D O I：

10.1016/0920-9964(96)00024-2

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Antagonists of the N-methyl-D-Aspartate (NMDA) subtype of glutamate receptor (e.g., phencyclidine, ketamine, MK-801) cause a schizophrenia-like psychosis in humans and neurotoxicity in the adult rat brain. We report here that clozapine and structurally related agents (olanzapine, fluperlapine, loxapine, amoxapine) can prevent NMDA antagonist neurotoxicity in the rat with a rank order corresponding to their ability to mimic the antipsychotic properties of clozapine.

引用

页码：33 / 37

页数：5

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