Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2′dG

被引：225

作者：

Hersch, SM

Gevorkian, S

Marder, K

Moskowitz, C

Feigin, A

Cox, M

Como, P

Zimmerman, C

Lin, M

Zhang, L

Ulug, AM

Beal, MF

Matson, W

Bogdanov, M

Ebbel, E

Zaleta, A

Kaneko, Y

Jenkins, B

Hevelone, N

Zhang, H

Yu, H

Schoenfeld, D

Ferrante, R

Rosas, HD

机构：

[1] MassGen Inst Neurogenerat Dis, Dept Neurol, Charlestown, MA 02129 USA

[2] MassGen Inst Neurogenerat Dis, Dept Biostat, Charlestown, MA 02129 USA

[3] Massachusetts Gen Hosp, Charlestown, MA USA

[4] Harvard Univ, Sch Med, Charlestown, MA USA

[5] Columbia Univ, Ctr Parkinsons Dis & Other Movement Disorders, New York, NY 10027 USA

[6] Columbia Univ, Dept Neurol, Sergievsky Ctr, New York, NY 10027 USA

[7] Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10027 USA

[8] N Shore LIJ Hlth Syst, Inst Med Res, Ctr Neurosci, Manhasset, NY USA

[9] Univ Rochester, Dept Neurol, Rochester, NY USA

[10] Cornell Univ, Weill Med Coll, Dept Neurol, New York, NY USA

[11] Cornell Univ, Weill Med Coll, Dept Neurosci, New York, NY USA

[12] Cornell Univ, Weill Med Coll, Dept Radiol, New York, NY USA

[13] Geriatr Res & Educ & Clin Ctr, Bedford, MA USA

[14] Edith Nourse Vet Adm Med Ctr, Bedford, MA USA

[15] Boston Univ, Sch Med, Dept Neurol Pathol, Boston, MA USA

[16] Boston Univ, Sch Med, Dept Psychiat, Boston, MA USA

[17] Boston Univ, Sch Med, Dept Biochem, Boston, MA USA

来源：

NEUROLOGY | 2006年 / 66卷 / 02期

关键词：

D O I：

10.1212/01.wnl.0000194318.74946.b6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In a randomized, double-blind, placebo-controlled study in 64 subjects with Huntington disease (HD), 8 g/day of creatine administered for 16 weeks was well tolerated and safe. Serum and brain creatine concentrations increased in the creatine-treated group and returned to baseline after washout. Serum 8-hydroxy-2=-deoxyguanosine (8OH2'dG) levels, an indicator of oxidative injury to DNA, were markedly elevated in HD and reduced by creatine treatment.

引用

页码：250 / 252

页数：3

共 10 条

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