Synthesis of 4-(Carbonyloxyphenyl)-1,4-Dihydropyridines as Potential Antihypertensive Agents

被引：8

作者：

Bansal, Ranju ^{[1
]}

Narang, Gaurav ^{[1
]}

Calle, Carmen ^{[2
]}

Carron, Rosalia ^{[2
]}

Pemberton, Karen ^{[3
]}

Harvey, Alan L. ^{[4
,5
]}

机构：

[1] Punjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India

[2] Univ Salamanca, Fac Farm, Dept Fisiol & Farmacol, E-37007 Salamanca, Spain

[3] Thistle Technol, Branford, CT 06405 USA

[4] Univ Strathclyde, Strathclyde Inst Drug Res, Glasgow G4 0NR, Lanark, Scotland

[5] Univ Strathclyde, Dept Physiol & Pharmacol, Glasgow G4 0NR, Lanark, Scotland

来源：

DRUG DEVELOPMENT RESEARCH | 2013年 / 74卷 / 01期

关键词：

calcium channel blockers; 1; 4-dihydropyridines; vasodilators; antihypertensive activity; Hantzsch synthesis; CALCIUM; 1,4-DIHYDROPYRIDINES; ANTAGONIST;

D O I：

10.1002/ddr.21056

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Preclinical Research A series of novel symmetric and asymmetric 4-(carbonyloxyphenyl)-1,4-dihydropyridines (DHPs) was synthesized and evaluated for calcium channel blocking, vasodilatory and antihypertensive properties. Some of these new DHPs displayed potent calcium channel blocking and good vasodilatory activities. Heart rate remained relatively constant in comparison with blood pressure changes in the case of these newly synthesized compounds, thereby decreasing the probability of reflex tachycardia, a major side effect of nifedipine. The most potent compound, ethyl methyl 4-(3-isopropylcarbonyloxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (14c) exhibited antihypertensive activity comparable with the standard drugnifedipine.

引用

页码：50 / 61

页数：12

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