The NLRP3 inflammasome: Role in metabolic disorders and regulation by metabolic pathways

被引：76

作者：

Jiang, Danlu ^{[1
,3
]}

Chen, Sheng ^{[1
,3
]}

Sun, Ruyu ^{[1
,3
]}

Zhang, Xue ^{[2
]}

Wang, Di ^{[1
]}

机构：

[1] Inst Immunol, Hangzhou, Zhejiang, Peoples R China

[2] Dept Pathol & Pathophysiol, Hangzhou, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China

来源：

CANCER LETTERS | 2018年 / 419卷

关键词：

NLRP3; inflammasome; Metabolic disorder; Metabolic pathway; IL-1; beta; IL-18; FATTY-ACID OXIDATION; ADIPOSE-TISSUE INFLAMMATION; AMYLOID-BETA-PEPTIDE; PYRUVATE-KINASE M2; KAPPA-B; INSULIN-RESISTANCE; PROMOTES NLRP3; TRIGLYCERIDE ACCUMULATION; ALZHEIMERS-DISEASE; ISCHEMIC-STROKE;

D O I：

10.1016/j.canlet.2018.01.034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells: they mediate the activation of caspase-1, leading to cellular pyroptosis. So far, a variety of studies on inflammasomes have emerged, and the best-studied is the NLRP3 inflammasome that is involved in many inflammatory responses. Furthermore, its relationship with metabolism is gaining increasing attention in this field. In this review, we discuss the importance of the NLRP3 inflammasome in metabolic disorders and its close association with metabolic pathways. (C) 2018 Elsevier B.V. All rights reserved.

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收藏

页码：8 / 19

页数：12

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