Mycothiol, 1-O-(2'-[N-acetyl-L-cysteinyl]amido-2'-deoxy-alpha-D-glucopyranosyl)-D-myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase

被引：52

作者：

MissetSmits, M

vanOphem, PW

Sakuda, S

Duine, JA

机构：

[1] DELFT UNIV TECHNOL,DEPT MICROBIOL & ENZYMOL,NL-2628 BC DELFT,NETHERLANDS

[2] NORTHEASTERN UNIV,DEPT BIOL,BOSTON,MA 02115

[3] UNIV TOKYO,DEPT APPL BIOL CHEM,TOKYO,JAPAN

来源：

FEBS LETTERS | 1997年 / 409卷 / 02期

关键词：

mycothiol; formaldehyde dehydrogenase; glutathione; actinomycetes; alcohol dehydrogenase class III;

D O I：

10.1016/S0014-5793(97)00510-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two different NAD/coenzyme-dependent formaldehyde dehydrogenases exist, the well-known NAD/GSH-dependent (EC 1.2.1.1) and the more recently discovered NAD/Factor-dependent enzyme, The GSH-dependent one has been found in eukaryotes and Gram-negative bacteria, the Factor-dependent one in two different Gram-positive bacteria. Previous work also shelved that Factor and GSH are not interchangeable in the enzymatic reactions. Here it is revealed that the Factor is identical to mycothiol (MySH), 1-O-(2'-[N-acetyl-L-cysteinyl]amido-2' -deoxy-alpha-D-glucopyranosyl)-D-myo-inositol, a thiol compound which has recently been detected in Actinomycetes, Thus, MySH is GSH's companion as it is the coenzyme for the enzyme which henceforth can be indicated as NAD/MySH-dependent formaldehyde dehydrogenase. (C) 1997 Federation of European Biochemical Societies.

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页码：221 / 222

页数：2

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