Synthesis and sar of thioester and thiol inhibitors of IMP-1 metallo-β-lactamase

被引：62

作者：

Greenlee, ML

Laub, JB

Balkovec, JM

Hammond, ML

Hammond, GG

Pompliano, DL

Epstein-Toney, JH

机构：

[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Biochem, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(99)00425-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Potent thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2549 / 2554

页数：6

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