Effect of single and repeated doses of a new nitroderivative of acetylsalicylic acid on platelet TXA(2) production in rats

被引：16

作者：

Cuzzolin, L ^{[1
]}

Adami, A ^{[1
]}

Degan, M ^{[1
]}

Crivellente, F ^{[1
]}

Bonapace, S ^{[1
]}

Minuz, P ^{[1
]}

Benoni, G ^{[1
]}

机构：

[1] UNIV VERONA, INST INTERNAL MED, I-37100 VERONA, ITALY

来源：

LIFE SCIENCES | 1996年 / 58卷 / 11期

关键词：

thromboxane A(2) production; acetylsalicylic acid nitroderivative;

D O I：

10.1016/0024-3205(96)00038-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of a new ASA-nitroderivative compound, NCX 4016 (ASA-NO2), on platelet TXA(2) synthesis after single and repeated doses in the rat were investigated. Compared to ASA, cumulative doses of ASA-NO2 showed similar inhibitory effects on platelet TXA(2) synthesis and significant increases in nitrite/nitrate plasma concentrations 1 h after the last drug administration: 24 h later nitrite/nitrate plasma levels returned to the control values, while serum TXA(2) concentrations did not change. A time-course study after a single dose of ASA-NO2 showed a significant inhibition of platelet TXA(2) production also 24 h after drug administration and a significant increase in nitrite/nitrate plasma levels until 10 h.

引用

页码：PL207 / PL210

页数：4

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