Selenocysteine-containing proteins in mammals

被引:86
作者
Gladyshev, VN [1 ]
Hatfield, DL
机构
[1] Univ Nebraska, Dept Biochem, Lincoln, NE 68588 USA
[2] NCI, Sect Mol Biol Selenium, Basic Res Lab,Div Basic Sci, NIH, Bethesda, MD 20892 USA
关键词
selenocysteine; selenoproteins; selenoenzymes; glutathione peroxidase; iodothyronine deiodinase; thioredoxin reductase; selenoprotein P; codon UGA;
D O I
10.1159/000025383
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Since the recent discovery of selenocysteine as the 21st amino acid in protein, the field of selenium biology has rapidly expanded. Twelve mammalian selenoproteins have been characterized to date and each contains selenocysteine that is incorporated in response to specific UGA code words. These selenoproteins have different cellular functions, but in those selenoproteins for which the function is known, selenocysteine is located at the active center. The presence of selenocysteine at critical sites in naturally occurring selenoproteins provides an explanation for the important role of selenium in human health and development. This review describes known mammalian selenoproteins and discusses recent developments and future directions in the selenium field.
引用
收藏
页码:151 / 160
页数:10
相关论文
共 103 条
  • [1] 1-CHLORO-2,4-DINITROBENZENE IS AN IRREVERSIBLE INHIBITOR OF HUMAN THIOREDOXIN REDUCTASE - LOSS OF THIOREDOXIN DISULFIDE REDUCTASE-ACTIVITY IS ACCOMPANIED BY A LARGE INCREASE IN NADPH OXIDASE ACTIVITY
    ARNER, ESJ
    BJORNSTEDT, M
    HOLMGREN, A
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (08) : 3479 - 3482
  • [2] Aumann KD, 1997, BIOMED ENVIRON SCI, V10, P136
  • [3] Baker A, 1997, CANCER RES, V57, P5162
  • [4] Glutathione peroxidase protects mice from viral-induced myocarditis
    Beck, MA
    Esworthy, RS
    Ho, YS
    Chu, FF
    [J]. FASEB JOURNAL, 1998, 12 (12) : 1143 - 1149
  • [5] Mouse models of human disease .1. Techniques and resources for genetic analysis in mice
    Bedell, MA
    Jenkins, NA
    Copeland, NG
    [J]. GENES & DEVELOPMENT, 1997, 11 (01) : 1 - 10
  • [6] EVIDENCE FOR SPECIFIC SELENIUM TARGET TISSUES AND NEW BIOLOGICALLY IMPORTANT SELENOPROTEINS
    BEHNE, D
    HILMERT, H
    SCHEID, S
    GESSNER, H
    ELGER, W
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 966 (01) : 12 - 21
  • [7] Newly found selenium-containing proteins in the tissues of the rat
    Behne, D
    Kyriakopoeulos, A
    WeissNowak, C
    Kalckloesch, M
    Westphal, C
    Gessner, H
    [J]. BIOLOGICAL TRACE ELEMENT RESEARCH, 1996, 55 (1-2) : 99 - 110
  • [8] Selenoprotein W of rat muscle binds glutathione and an unknown small molecular weight moiety
    Beilstein, MA
    Vendeland, SC
    Barofsky, E
    Jensen, ON
    Whanger, PD
    [J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 1996, 61 (02) : 117 - 124
  • [9] FUNCTIONAL-CHARACTERIZATION OF THE EUKARYOTIC SECIS ELEMENTS WHICH DIRECT SELENOCYSTEINE INSERTION AT UGA CODONS
    BERRY, MJ
    BANU, L
    HARNEY, JW
    LARSEN, PR
    [J]. EMBO JOURNAL, 1993, 12 (08) : 3315 - 3322
  • [10] RECOGNITION OF UGA AS A SELENOCYSTEINE CODON IN TYPE-I DEIODINASE REQUIRES SEQUENCES IN THE 3' UNTRANSLATED REGION
    BERRY, MJ
    BANU, L
    CHEN, Y
    MANDEL, SJ
    KIEFFER, JD
    HARNEY, JW
    LARSEN, PR
    [J]. NATURE, 1991, 353 (6341) : 273 - 276