Association between serum uric acid and the metabolic syndrome among a middle- and old-age Chinese population

被引：75

作者：

Dai, Xiayun ^{[1
,2
]}

Yuan, Jing ^{[1
,2
]}

Yao, Ping ^{[1
,2
]}

Yang, Binyao ^{[1
,2
]}

Gui, Lixuan ^{[1
,2
]}

Zhang, Xiaomin ^{[1
,2
]}

Guo, Huan ^{[1
,2
]}

Wang, Youjie ^{[1
,2
]}

Chen, Weihong ^{[1
,2
]}

Wei, Sheng ^{[1
,2
]}

Miao, Xiaoping ^{[1
,2
]}

Li, Xiulou ^{[3
,4
]}

Min, Xinwen ^{[3
,4
]}

Yang, Handong ^{[3
,4
]}

Fang, Weimin ^{[1
,2
]}

Liang, Yuan ^{[1
,2
]}

Hu, Frank B. ^{[2
,5
]}

Wu, Tangchun ^{[1
]}

He, Meian ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Inst Occupat Med, Sch Publ Hlth, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Minist Educ MOE, Key Lab Environm & Hlth, Sch Publ Hlth,Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

[3] Dongfeng Motor Corp, Dongfeng Cent Hosp, Shiyan, Hubei, Peoples R China

[4] Hubei Univ Med, Shiyan, Hubei, Peoples R China

[5] Harvard Univ, Sch Med, Dept Nutr & Epidemiol, Boston, MA USA

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2013年 / 28卷 / 08期

关键词：

Uric acid; Variation; Metabolic syndrome; GENOME-WIDE ASSOCIATION; MENDELIAN RANDOMIZATION; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; URATE TRANSPORTER; RISK-FACTORS; LEVEL; MORTALITY; TRAITS; GENES;

D O I：

10.1007/s10654-013-9829-4

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Our aim was to study whether there is causal association between serum uric acid and metabolic syndrome (MetS). A cross-sectional study was performed, including a total of 27,009 subjects (23,345 subjects having uric acid data) from the Dongfeng-Tongji Cohort study. The MetS was defined by the International Diabetes Foundation criteria of 2005. Association analysis was performed by logistic regression. A genetic risk score was calculated by adding the uric acid increasing alleles in two SNPs (rs11722228 in SLC2A9 and rs2231142 in ABCG2) which were identified from our genome-wide association study on uric acid levels. The causal association was examined by mendelian randomization analysis. Among a middle- and old-age Chinese population, serum uric acid concentrations were strongly associated with the risk of MetS and its several components (P < 0.0001). The effects were stronger in women than in men. Despite the lack of statistical significance, both SNPs exhibited a trend with increased MetS risk (rs11722228, OR = 1.06, 95 % CI 0.99-1.14; rs2231142, OR = 1.02, 95 % CI 0.95-1.10), consistent with their increasing uric acid effects. Each additional uric acid increasing allele in the genetic risk score was associated with 3 % increased MetS risk (OR = 1.03, 95 % CI 0.98-1.09; P = 0.23). Further adjustment for serum uric acid attenuated the trend of individual SNP and genetic risk score with increased MetS risk (all OR < 1.0). These findings suggested that serum uric acid was associated with MetS risk in a middle- and old-age Chinese population. Whether this association was causal remained to be investigated in the future studies.

引用

页码：669 / 676

页数：8

共 35 条

[1] The metabolic syndrome - a new worldwide definition [J].