Trends in colorectal incidence by anatomic subsite from 1985 to 2005: a population-based study

被引:23
作者
Caldarella, A. [1 ]
Crocetti, E. [1 ]
Messerini, L. [2 ]
Paci, E. [1 ]
机构
[1] Inst Study & Canc Prevent ISPO, Clin & Descript Epidemiol Unit, I-50141 Florence, Italy
[2] Univ Florence, Dept Med & Surg Crit Care, Sect Pathol Anat, Florence, Italy
关键词
Colorectal cancer; Incidence; Proximal; Distal; CANCER INCIDENCE RATES; COLON-CANCER; TUMOR LOCATION; UNITED-STATES; SHIFT; EXPRESSION; CARCINOMA; SURVIVAL; STAGE;
D O I
10.1007/s00384-013-1672-2
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Conflicting results on the shift of right-left ratio in colon cancer incidence have been reported. We examine incidence trends by subsite in a population-based study. Colorectal cancer cases diagnosed in the 1985-2005 period were identified through the Tuscany Cancer Registry. Colon subsite was defined as proximal and distal; gender, age at diagnosis, histology, and stage were analyzed. Average annual incidence and age-specific rates according to subsite were calculated. A total of 21,160 colorectal cancer cases were extracted; in 18,311 cases, the subsite was identified: 6,916 rectal, 5,239 proximal, and 6,156 distal. A larger proportion of distal colon cancers presented as early stage when compared with proximal. Incidence of rectal and distal colon cancer remained stable, while proximal colon cancer incidence increased. Proximal colon cancer incidence rate increased through the period. Temporal variations in the incidence rate by subsite could suggest different carcinogenic pathways of right- and left-sided colon cancer.
引用
收藏
页码:637 / 641
页数:5
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