Oxidized low density lipoprotein and atherosclerosis

被引:54
作者
Devaraj, S
Jialal, I
机构
[1] UNIV TEXAS,SW MED CTR,DEPT PATHOL & INTERNAL MED,DALLAS,TX 75235
[2] UNIV TEXAS,SW MED CTR,CTR HUMAN NUTR,DALLAS,TX 75235
[3] UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,DALLAS,TX 75235
关键词
low density lipoprotein; atherosclerosis; lipid peroxidation; alpha-tocopherol; ascorbate;
D O I
10.1007/BF02592979
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Atherosclerosis is the leading cause of morbidity and mortality in western society. The most important risk factors for atherosclerosis include smoking, hypertension, dyslipidemia, diabetes and a family history of premature atherosclerosis. Several studies indicate that an increased plasma low density lipoprotein (LDL) cholesterol constitutes a major risk factor for atherosclerosis. Many data support a proatherogenic role for oxidized LDL and its in vivo existence. The oxidative susceptibility of LDL is increased with established cardiovascular risk factors, such as diabetes, smoking and dyslipidemia. Supplementation with antioxidants such as ascorbate and alpha-tocopherol can decrease LDL oxidation as well as cardiovascular mortality and thus shows promise in the prevention of atherosclerosis.
引用
收藏
页码:178 / 184
页数:7
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