The absolute configuration of sertraline (Zoloft) hydrochloride

被引：17

作者：

Caruso, F

Besmer, A

Rossi, M

机构：

[1] CNR, Ist Strutturist Chim, I-00016 Monterotondo, Italy

[2] Vassar Coll, Dept Chem, Poughkeepsie, NY 12604 USA

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1999年 / 55卷

关键词：

D O I：

10.1107/S0108270199008343

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the results of a crystal structure determination of the S,S stereoisomer of sertraline (Zoloft) hydrochloride {[(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthyl]methylammonium chloride, C17H18Cl2N+. Cl-}, which is the active form used as an antidepressant in humans. The conformation of sertraline has two planar phenyl rings that are approximately perpendicular to each other, and an unsaturated ring in a half-chair conformation.

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页码：1712 / 1714

页数：3

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