First synthesis of caerulomycin C

被引：64

作者：

Trecourt, F ^{[1
]}

Gervais, B ^{[1
]}

Mallet, M ^{[1
]}

Queguiner, G ^{[1
]}

机构：

[1] INST NATL SCI APPL ROUEN,URA CNRS 1429,INST RECH CHIM ORGAN FINE,LAB CHIM ORGAN FINE & HETEROCYL,F-76131 MONT ST AIGNAN,FRANCE

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 05期

关键词：

D O I：

10.1021/jo950823k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of caerulomycin C (1), an antibiotic produced by Streptomyces caeruleus, is reported. This molecule, which exhibits a 2,3,4,6-tetrasubstituted pyridine structure, was prepared from 3,4-dimethoxypyridine in a five-step sequence. The methodology involves metalation, transmetalation, aromatic cross-coupling, and halogen migration reactions.

引用

页码：1673 / 1676

页数：4

共 20 条

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