Cancer cell metabolism: Warburg and beyond

被引：1917

作者：

Hsu, Peggy P. ^{[1
,2
,3
]}

Sabatini, David M. ^{[1
,2
,3
,4
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02142 USA

[3] Broad Inst, Cambridge, MA 02142 USA

[4] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

CELL | 2008年 / 134卷 / 05期

关键词：

D O I：

10.1016/j.cell.2008.08.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg effect and establish a framework for understanding its contribution to the altered metabolism of cancer cells.

引用

页码：703 / 707

页数：5

共 41 条

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