A common genetic background could explain early-onset Crohn's disease

被引：19

作者：

Bianco, Anna Monica ^{[1
]}

Zanin, Valentina ^{[1
]}

Girardelli, Martina

Magnolato, Andrea ^{[1
]}

Martellossi, Stefano

Tommasini, Alberto

Marcuzzi, Annalisa

Crovella, Sergio ^{[1
]}

机构：

[1] Univ Trieste, Inst Maternal & Child Hlth IRCCS Burlo Garofolo, I-34134 Trieste, Italy

来源：

MEDICAL HYPOTHESES | 2012年 / 78卷 / 04期

关键词：

INFLAMMATORY-BOWEL-DISEASE; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; NOD2; CHILDREN; PATHOGENESIS; RISK; SNPS; AGE; IBD;

D O I：

10.1016/j.mehy.2012.01.023

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Crohn's disease (CD) is a multifactorial disease, in which environmental, microbial and genetic factors play important roles. CD is characterized by a chronic granulomatous inflammation by necrotic scarring with aspects of full-thickness wall. In spite of affecting mainly young adults, sometimes, CD can be present in the first year of life (early onset Crohn disease, EOCD) showing an unpredictable course and being often more severe than at older ages. In this paper we propose the hypothesis that EOCD patients should be analyzed using a Mendelian approach with family studies aimed to identify new loci directly involved in the early onset Crohn's disease. So we will leave the classic association study approach used until now for the identification of genes responsible for susceptibility to CD and propose linkage family analysis as alternative and powerful tool for the identification of new genetic variants associated with familiar cases of EOCD. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：520 / 522

页数：3

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