Double-strand breaks and tumorigenesis

被引：178

作者：

Pierce, AJ

Stark, JM

Araujo, FD

Moynahan, ME

Berwick, M

Jasin, M

机构：

[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

来源：

TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 11期

关键词：

D O I：

10.1016/S0962-8924(01)82296-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The establishment of connections between biochemical defects and clinical disease is a major goal of modern molecular genetics. In this review, we examine the current literature that relates defects in the two major DNA double-strand-break repair pathways - homologous recombination and nonhomologous end-joining - with the development of human tumors. Although definitive proof has yet to be obtained, the current literature is highly suggestive of such a link.

引用

收藏

页码：S52 / S59

页数：8

相关论文

共 71 条

[1]

Bell DW, 1999, CANCER RES, V59, P3883

[2] The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin [J].

Bhattacharyya, A ;

Ear, US ;

Koller, BH ;

Weichselbaum, RR ;

Bishop, DK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (31) :23899-23903

[3] Genetic polymorphisms in DNA repair genes and risk of lung cancer [J].

Butkiewicz, D ;

Rusin, M ;

Enewold, L ;

Shields, PG ;

Chorazy, M ;

Harris, CC .

CARCINOGENESIS, 2001, 22 (04) :593-597

[4] The importance of repairing stalled replication forks [J].

Cox, MM ;

Goodman, MF ;

Kreuzer, KN ;

Sherratt, DJ ;

Sandler, SJ ;

Marians, KJ .

NATURE, 2000, 404 (6773) :37-41

[5] Recombinational DNA repair in bacteria and the RecA protein [J].

Cox, MM .

PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 63, 2000, 63 :311-366

[6] Role of BRCA2 in control of the RAD51 recombination and DNA repair protein [J].

Davies, AA ;

Masson, JY ;

Mcllwraith, MJ ;

Stasiak, AZ ;

Stasiak, A ;

Venkitaraman, AR ;

West, SC .

MOLECULAR CELL, 2001, 7 (02) :273-282

[7] Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice [J].

Deans, B ;

Griffin, CS ;

Maconochie, M ;

Thacker, J .

EMBO JOURNAL, 2000, 19 (24) :6675-6685

[8] DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation [J].

Difilippantonio, MJ ;

Zhu, J ;

Chen, HT ;

Meffre, E ;

Nussenzweig, MC ;

Max, EE ;

Ried, T ;

Nussenzweig, A .

NATURE, 2000, 404 (6777) :510-514

[9] Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange [J].

Dronkert, MLG ;

Beverloo, HB ;

Johnson, RD ;

Hoeijmakers, JHJ ;

Jasin, M ;

Kanaar, R .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (09) :3147-3156

[10] Disruption of mouse RAD54 reduces ionizing radiation resistance [J].

Essers, J ;

Hendriks, RW ;

Swagemakers, SMA ;

Troelstra, C ;

deWit, J ;

Bootsma, D ;

Hoeijmakers, JHJ ;

Kanaar, R .

CELL, 1997, 89 (02) :195-204

← 1 2 3 4 5 6 7 8 →