Translation drives mRNA quality control

被引：292

作者：

Shoemaker, Christopher J. ^{[1
]}

Green, Rachel ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Howard Hughes Med Inst, Baltimore, MD 21205 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 06期

关键词：

NONSENSE-MEDIATED DECAY; NO-GO DECAY; EXON JUNCTION COMPLEX; E3 UBIQUITIN LIGASE; TERMINATION CODON; ENDONUCLEOLYTIC CLEAVAGE; SACCHAROMYCES-CEREVISIAE; STRUCTURAL BASIS; ACCELERATED DEGRADATION; CONTROL PATHWAYS;

D O I：

10.1038/nsmb.2301

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There are three predominant forms of co-translational mRNA surveillance: nonsense-mediated decay (NMD), no-go decay (NGD) and nonstop decay (NSD). Although discussion of these pathways often focuses on mRNA fate, there is growing consensus that there are other important outcomes of these processes that must be simultaneously considered. Here, we seek to highlight similarities between NMD, NGD and NSD and their probable origins on the ribosome during translation.

引用

页码：594 / 601

页数：8

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