Community-acquired Acinetobacter baumannii: clinical characteristics, epidemiology and pathogenesis

被引:153
作者
Dexter, Carina [1 ]
Murray, Gerald L. [1 ]
Paulsen, Ian T. [2 ]
Peleg, Anton Y. [1 ,3 ]
机构
[1] Monash Univ, Dept Microbiol, Sch Biomed Sci, Clayton, Vic 3168, Australia
[2] Macquarie Univ, Dept Chem & Biomol Sci, Sydney, NSW 2109, Australia
[3] Alfred Hosp, Dept Infect Dis, Melbourne, Vic, Australia
基金
英国医学研究理事会;
关键词
A; baumannii; CA-Ab; community-acquired pneumonia; ethanol; DIABETES-MELLITUS; T-CELL; PNEUMONIA; MENINGITIS; INFECTIONS; ETHANOL; DYSFUNCTION; ALCOHOL; STRAINS; NEUTROPHILS;
D O I
10.1586/14787210.2015.1025055
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Community-acquired Acinetobacter baumannii (CA-Ab) is a rare but serious cause of community-acquired pneumonia in tropical regions of the world. CA-Ab infections predominantly affect individuals with risk factors, which include excess alcohol consumption, diabetes mellitus, smoking and chronic lung disease. CA-Ab pneumonia presents as a surprisingly fulminant course and is characterized by a rapid onset of fever, severe respiratory symptoms and multi-organ dysfunction, with a mortality rate reported as high as 64%. It is unclear whether the distinct clinical syndrome caused by CA-Ab is because of host predisposing factors or unique bacterial characteristics, or a combination of both. Deepening our understanding of the drivers of overwhelming CA-Ab infection will provide important insights into preventative and therapeutic strategies.
引用
收藏
页码:567 / 573
页数:7
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