The chemokine system: redundancy for robust outputs

被引：592

作者：

Mantovani, A

机构：

[1] Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy

[2] Univ Brescia, Dept Biotechnol, Sect Gen Pathol, I-25121 Brescia, Italy

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 06期

关键词：

D O I：

10.1016/S0167-5699(99)01469-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chemokines are redundant in their action an target cells and promiscuous in receptor usage. Moreover, certain cells concomitantly produce several chemokines with an overlapping spectrum of action. Here, Alberto Mantovani argues that such robustness provides a conceptual framework to understand these intriguing aspects of the chemokine system.

引用

页码：254 / 257

页数：4

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