Immunological Goings-on in Visceral Adipose Tissue

被引：348

作者：

Mathis, Diane ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Div Immunol, Dept Microbiol & Immunobiol, Boston, MA 02115 USA

来源：

CELL METABOLISM | 2013年 / 17卷 / 06期

关键词：

KILLER T-CELLS; DIET-INDUCED OBESITY; INVARIANT NKT CELLS; INSULIN-RESISTANCE; MACROPHAGE POLARIZATION; HEPATIC STEATOSIS; IMMUNE-SYSTEM; PPAR-GAMMA; FAT DEPOT; INFLAMMATION;

D O I：

10.1016/j.cmet.2013.05.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chronic, low-grade inflammation of visceral adipose tissue, and systemically, is a critical link between recent strikingly parallel rises in the incidence of obesity and type 2 diabetes. Macrophages have been recognized for some time to be critical participants in obesity-induced inflammation of adipose tissue. Of late, a score of other cell types of the innate and adaptive arms of the immune system have been suggested to play a positive or negative role in adipose tissue infiltrates. This piece reviews the existing data on these new participants; discusses experimental uncertainties, inconsistencies, and complexities; and puts forward a minimalist synthetic scheme.

引用

页码：851 / 859

页数：9

共 75 条

[1] The Human Visceral Fat Depot Has a Unique Inflammatory Profile [J].

Alvehus, Malin ;

Buren, Jonas ;

Sjostrom, Michael ;

Goedecke, Julia ;

Olsson, Tommy .

OBESITY, 2010, 18 (05) :879-883

[2] Adipose tissues as an ancestral immune organ:: Site-specific change in obesity [J].

Caspar-Bauguil, S ;

Cousin, B ;

Galinier, A ;

Segafredo, C ;

Nibbelink, M ;

André, A ;

Casteilla, L ;

Pénicaud, L .

FEBS LETTERS, 2005, 579 (17) :3487-3492

[3] Macrophage-mediated inflammation in metabolic disease [J].

Chawla, Ajay ;

Nguyen, Khoa D. ;

Goh, Y. P. Sharon .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (11) :738-749

[4] A guanidine-rich regulatory oligodeoxy-nucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation [J].

Cheng, Xiang ;

Wang, Jing ;

Xia, Ni ;

Yan, Xin-Xin ;

Tang, Ting-Ting ;

Chen, Han ;

Zhang, Hong-Jian ;

Liu, Juan ;

Kong, Wen ;

Sjoeberg, Sara ;

Folco, Eduardo ;

Libby, Peter ;

Liao, Yu-Hua ;

Shi, Guo-Ping .

EMBO MOLECULAR MEDICINE, 2012, 4 (10) :1112-1125

[5] PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells [J].

Cipolletta, Daniela ;

Feuerer, Markus ;

Li, Amy ;

Kamei, Nozomu ;

Lee, Jongsoon ;

Shoelson, Steven E. ;

Benoist, Christophe ;

Mathis, Diane .

NATURE, 2012, 486 (7404) :549-U151

[6] B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile [J].

DeFuria, Jason ;

Belkina, Anna C. ;

Jagannathan-Bogdan, Madhumita ;

Snyder-Cappione, Jennifer ;

Carr, Jordan David ;

Nersesova, Yanina R. ;

Markham, Douglas ;

Strissel, Katherine J. ;

Watkins, Amanda A. ;

Zhu, Min ;

Allen, Jessica ;

Bouchard, Jacqueline ;

Toraldo, Gianluca ;

Jasuja, Ravi ;

Obin, Martin S. ;

McDonnell, Marie E. ;

Apovian, Caroline ;

Denis, Gerald V. ;

Nikolajczyk, Barbara S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (13) :5133-5138

[7] Visceral Adipose Inflammation in Obesity Is Associated with Critical Alterations in Tregulatory Cell Numbers [J].

Deiuliis, Jeffrey ;

Shah, Zubair ;

Shah, Nilay ;

Needleman, Bradley ;

Mikami, Dean ;

Narula, Vimal ;

Perry, Kyle ;

Hazey, Jeffrey ;

Kampfrath, Thomas ;

Kollengode, Madhukar ;

Sun, Qinghua ;

Satoskar, Abhay R. ;

Lumeng, Carey ;

Moffatt-Bruce, Susan ;

Rajagopalan, Sanjay .

PLOS ONE, 2011, 6 (01)

[8] Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation [J].

Deng, Tuo ;

Lyon, Christopher J. ;

Minze, Laurie J. ;

Lin, Jianxin ;

Zou, Jia ;

Liu, Joey Z. ;

Ren, Yuelan ;

Yin, Zheng ;

Hamilton, Dale J. ;

Reardon, Patrick R. ;

Sherman, Vadim ;

Wang, Helen Y. ;

Phillips, Kevin J. ;

Webb, Paul ;

Wong, Stephen T. C. ;

Wang, Rong-fu ;

Hsueh, Willa A. .

CELL METABOLISM, 2013, 17 (03) :411-422

[9] Type 2 diabetes as an inflammatory disease [J].

Donath, Marc Y. ;

Shoelson, Steven E. .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (02) :98-107

[10] Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity [J].

Duffaut, Carine ;

Galitzky, Jean ;

Lafontan, Max ;

Bouloumie, Anne .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 384 (04) :482-485

← 1 2 3 4 5 6 7 8 →