Gene regulation of mammalian long non-coding RNA

被引：124

作者：

Bunch, Heeyoun ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Agr & Life Sci Bldg 1,Room 207,80 Dae Hak Ro, Daegu, South Korea

来源：

MOLECULAR GENETICS AND GENOMICS | 2018年 / 293卷 / 01期

关键词：

Long non-coding RNA; Transcriptional mechanism; Gene expression regulation; PIWI-INTERACTING RNAS; POLYMERASE-II; XIST RNA; POL II; MUSCLE DIFFERENTIATION; CELL-PROLIFERATION; X-INACTIVATION; ANTISENSE RNA; GENOME-WIDE; EXPRESSION;

D O I：

10.1007/s00438-017-1370-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

RNA polymerase II (Pol II) transcribes two classes of RNAs, protein-coding and non-protein-coding (ncRNA) genes. ncRNAs are also synthesized by RNA polymerases I and III (Pol I and III). In humans, the number of ncRNA genes exceeds more than twice that of protein-coding genes. However, the history of studying Pol II-synthesized ncRNA is relatively short. Since early 2000s, important biological and pathological functions of these ncRNA genes have begun to be discovered and intensively studied. And transcription mechanisms of long non-coding RNA (lncRNA) have been recently reported. Transcription of lncRNAs utilizes some transcription factors and mechanisms shared in that of protein-coding genes. In addition, tissue specificity in lncRNA gene expression has been shown. LncRNAs play essential roles in regulating the expression of neighboring or distal genes through different mechanisms. This leads to the implication of lncRNAs in a wide variety of biological pathways and pathological development. In this review, the newly discovered transcription mechanisms, characteristics, and functions of lncRNA are discussed.

引用

页码：1 / 15

页数：15

共 170 条

[1]

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans [J].