Direct tubulin polymerization perturbation contributes significantly to the induction of micronuclei in vivo

被引：18

作者：

terHaar, E

Day, BW

Rosenkranz, HS

机构：

[1] UNIV PITTSBURGH,DEPT ENVIRONM & OCCUPAT HLTH,PITTSBURGH,PA 15238

[2] UNIV PITTSBURGH,DEPT PHARMACEUT SCI,PITTSBURGH,PA 15238

[3] UNIV PITTSBURGH,INST CANC,PITTSBURGH,PA 15238

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1996年 / 350卷 / 02期

基金：

美国安德鲁·梅隆基金会;

关键词：

D O I：

10.1016/0027-5107(95)00175-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The computational analysis data presented indicate a significant mechanistic association between the ability of a chemical to cause tubulin polymerization perturbation (TPP), via direct interaction with the protein, and the in vivo induction of micronuclei (MN). Since it is known that TPP is not a genotoxic event, the analyses suggest that the induction of MN by a non-genotoxic mechanism is a significant alternate pathway.

引用

页码：331 / 337

页数：7

共 44 条

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