Role of phase variation of type 1 fimbriae in a uropathogenic Escherichia coli cystitis isolate during urinary tract infection

被引：49

作者：

Snyder, JA

Lloyd, AL

Lockatell, CV

Johnson, DE

Mobley, HLT

机构：

[1] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

[2] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

[3] Univ Maryland, Sch Med, Div Infect Dis, Baltimore, MD 21201 USA

[4] Dept Vet Affairs, Baltimore, MD 21201 USA

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 02期

关键词：

D O I：

10.1128/IAI.74.2.1387-1393.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type 1 fimbrial phase-locked mutants of uropathogenic Escherichia coli cystitis isolate F11 were used to assess the role of the invertible element during urinary tract infection. Compared to the wild type, the phase-locked off mutant was attenuated, and constitutive production of type 1 fimbriae by the phase-locked on mutant did not provide a competitive advantage.

引用

收藏

页码：1387 / 1393

页数：7

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