Clusterin prevents aggregation of neuropeptide 106-126 in vitro

被引：34

作者：

McHattie, S ^{[1
]}

Edington, N ^{[1
]}

机构：

[1] Univ London Royal Coll Vet Surg, London NW1 0TU, England

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 259卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1006/bbrc.1999.0781

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The prion/amyloid neuropeptide 106-126 spontaneously aggregates to form fibrillar structures in vitro. The aggregation in vitro could be prevented in a dose-related manner by clusterin, and the specificity of this action was confirmed by reversal with antibody to clusterin. The relevance of these observations is discussed in relation to previous observations that clusterin and PrPBSE colocalise in naturally occurring cases of BSE. (C) 1999 Academic Press.

引用

页码：336 / 340

页数：5

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