A detailed methodology of partial hepatectomy in the mouse

被引:33
作者
Boyce, Stephen [1 ]
Harrison, David [2 ]
机构
[1] Univ Edinburgh, Royal Infirm Edinburgh, Dept Surg, Edinburgh EH16 4SA, Midlothian, Scotland
[2] Western Gen Hosp, Edinburgh Canc Res Ctr, Edinburgh EH4 2XR, Midlothian, Scotland
关键词
D O I
10.1038/laban1108-529
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 [兽医学];
摘要
The technique of partial hepatectomy is widely used to model liver regeneration and cell cycle dynamics in vivo. Because murine gene expression can be manipulated relatively easily, partial hepatectomy in mice is a useful tool for exploring the contributions of different genes to such hepatic processes. The authors present a straightforward method of partial hepatectomy in the mouse.
引用
收藏
页码:529 / 532
页数:4
相关论文
共 11 条
[1]
Regulation of cyclin-dependent kinase inhibitor p21(WAF1/Cip1/Sdi1) gene expression in hepatic regeneration [J].
Albrecht, JH ;
Meyer, AH ;
Hu, MY .
HEPATOLOGY, 1997, 25 (03) :557-563
[2]
BUCHER NLR, 1964, CANCER RES, V24, P1611
[3]
Fas engagement accelerates liver regeneration after partial hepatectomy [J].
Desbarats, J ;
Newell, MK .
NATURE MEDICINE, 2000, 6 (08) :920-923
[4]
Partial hepatectomy in the mouse: Technique and perioperative management [J].
Greene, AK ;
Puder, M .
JOURNAL OF INVESTIGATIVE SURGERY, 2003, 16 (02) :99-102
[5]
Higgins GM, 1931, ARCH PATHOL, V12, P186
[6]
The p21Cip1 protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers [J].
Jaime, M ;
Pujol, MJ ;
Serratosa, J ;
Pantoja, C ;
Canela, N ;
Casanovas, O ;
Serrano, M ;
Agell, N ;
Bachs, O .
HEPATOLOGY, 2002, 35 (05) :1063-1071
[7]
Liver regeneration [J].
Koniaris, LG ;
McKillop, IH ;
Schwartz, SI ;
Zimmers, TA .
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2003, 197 (04) :634-659
[8]
Rodent models of partial hepatectomies [J].
Martins, Paulo N. A. ;
Theruvath, Tom P. ;
Neuhaus, Peter .
LIVER INTERNATIONAL, 2008, 28 (01) :3-11
[9]
Hepatic lobectomy and segmentectomy models using microsurgical techniques [J].
Martins, Paulo Ney Aguiar ;
Neuhaus, Peter .
MICROSURGERY, 2008, 28 (03) :187-191
[10]
Surgical anatomy of the liver, hepatic vasculature and bile ducts in the rat [J].
Martins, Paulo Ney Aguiar ;
Neuhaus, Peter .
LIVER INTERNATIONAL, 2007, 27 (03) :384-392