The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII

被引：37

作者：

Bowman, S ^{[1
]}

Churcher, C ^{[1
]}

Badcock, K ^{[1
]}

Brown, D ^{[1
]}

Chillingworth, T ^{[1
]}

Connor, R ^{[1
]}

Dedman, K ^{[1
]}

Devlin, K ^{[1
]}

Gentles, S ^{[1
]}

Hamlin, N ^{[1
]}

Hunt, S ^{[1
]}

Jagels, K ^{[1
]}

Lye, G ^{[1
]}

Moule, S ^{[1
]}

Odell, C ^{[1
]}

Pearson, D ^{[1
]}

Rajandream, M ^{[1
]}

Rice, P ^{[1
]}

Skelton, J ^{[1
]}

Walsh, S ^{[1
]}

Whitehead, S ^{[1
]}

Barrell, B ^{[1
]}

机构：

[1] SANGER CTR,CAMBRIDGE CB10 1SA,ENGLAND

来源：

NATURE | 1997年 / 387卷 / 6632期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/387s090

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Systematic sequencing of the genome of Saccharomyces cerevisiae has revealed thousands of new predicted genes and allowed analysis of long-range features of chromosomal organization. Generally, genes and predicted genes seem to be distributed evenly throughout the genome, having no overall preference for DNA strand. Apart from the smaller chromosomes, which can have substantially lower gene density in their telomeric: regions(1-3), there is a consistent average of one open reading frame (ORF) approximately every two kilobases. However, one of the most surprising findings for a eukaryote with approximately 6,000 genes was the amount of apparent redundancy in its genome. This redundancy occurs both between individual ORFs and over more extensive chromosome regions, which have been duplicated preserving gene order and orientation(4-6). Here we report the entire nucleotide sequence of chromosome XIII, the sixth-largest S. cerevisiae chromosome, and demonstrate that its features and organization are consistent with those observed for other S. cerevisiae chromosomes. Analysis revealed 459 ORFs, 284 have not been identified previously. Both intra- and interchromosomal duplications of regions of this chromosome have occurred.

引用

页码：90 / 93

页数：4

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