Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

被引：496

作者：

Meyre, David ^{[1
]}

Delplanque, Jerome ^{[1
]}

Chevre, Jean-Claude ^{[1
]}

Lecoeur, Cecile ^{[1
]}

Lobbens, Stephane ^{[1
]}

Gallina, Sophie ^{[1
]}

Durand, Emmanuelle ^{[1
]}

Vatin, Vincent ^{[1
]}

Degraeve, Franck ^{[1
]}

Proenca, Christine ^{[1
]}

Gaget, Stefan ^{[1
]}

Koerner, Antje ^{[2
]}

Kovacs, Peter ^{[3
]}

Kiess, Wieland ^{[2
]}

Tichet, Jean ^{[4
]}

Marre, Michel ^{[5
,6
]}

Hartikainen, Anna-Liisa ^{[7
]}

Horber, Fritz ^{[8
,9
]}

Potoczna, Natascha ^{[8
,9
]}

Hercberg, Serge ^{[10
]}

Levy-Marchal, Claire ^{[11
,12
]}

Pattou, Francois ^{[13
]}

Heude, Barbara ^{[14
,15
]}

Tauber, Maithe ^{[16
]}

McCarthy, Mark I. ^{[17
,18
,19
]}

Blakemore, Alexandra I. F. ^{[20
]}

Montpetit, Alexandre ^{[21
,22
]}

Polychronakos, Constantin ^{[21
,22
]}

Weill, Jacques ^{[23
]}

Coin, Lachlan J. M. ^{[24
]}

Asher, Julian

Elliott, Paul ^{[24
]}

Jarvelin, Marjo-Riitta ^{[24
,25
]}

Visvikis-Siest, Sophie ^{[26
]}

Balkau, Beverley ^{[14
,15
]}

Sladek, Rob ^{[21
,22
]}

Balding, David ^{[24
]}

Walley, Andrew

Dina, Christian ^{[1
]}

Froguel, Philippe ^{[1
]}

机构：

[1] Inst Pasteur, Inst Biol, CNRS 8090, F-59000 Lille, France

[2] Univ Leipzig, Univ Hosp Children & Adolescents, D-04103 Leipzig, Germany

[3] Univ Leipzig, Interdisciplinary Ctr Clin Res, D-04103 Leipzig, Germany

[4] Inst Inter Reg Sante, F-37521 La Riche, France

[5] Bichat Claude Bernard Univ Hosp, AP HP, Dept Endocrinol, F-75018 Paris, France

[6] Univ Paris 07, INSERM, U695, F-75007 Paris, France

[7] Univ Oulu, Dept Clin Sci Obstet & Gynecol, Oulu 90014, Finland

[8] Univ Bern, CH-3012 Bern, Switzerland

[9] Klin Lindberg, CH-8400 Winterthur, Switzerland

[10] Univ Paris 13, Ctr Rech Nutr Humaine, UMR, U557,INSERM,U1125,INRA, F-93017 Bobigny, France

[11] Univ Paris Diderot, FR-75205 Paris 13, France

[12] INSERM, U690, FR-75019 Paris, France

[13] Ctr Hosp Reg Univ Lille, INSERM, U859, F-59000 Lille, France

[14] Univ Paris 11, F-91405 Orsay, France

[15] INSERM, U780, F-94807 Villejuif, France

[16] CHU, INSERM, U563, Childrens Hosp, F-31000 Toulouse, France

[17] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England

[18] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3, England

[19] Oxford Natl Inst Hlth Res Biomed Res Ctr, Oxford OX3, England

[20] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sect Genom Med, London W12 0HS, England

[21] McGill Univ, Montreal, PQ H3A 1A, Canada

[22] Genome Quebec Innovat Ctr, Montreal, PQ H3A 1A, Canada

[23] Jeanne de Flandre Hosp, Pediat Endocrine Unit, F-59000 Lille, France

[24] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England

[25] Univ Oulu, Inst Hlth Sci, Natl Publ Hlth Inst, Dept Child & Adolescent Hlth, Oulu 90014, Finland

[26] INSERM, Cardiovasc Genet Team, Ctr Invest Clin, F-54000 Nancy, France

来源：

NATURE GENETICS | 2009年 / 41卷 / 02期

基金：

英国医学研究理事会;

关键词：

CHOLESTEROL TRAFFICKING; C-DISEASE; PROTEIN; EXPRESSION; MICE;

D O I：

10.1038/ng.301

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).

引用

页码：157 / 159

页数：3

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