Effects of partial sympathectomy of brown fat or of adrenomedullectomy on catecholamine metabolism in cold-reared rats

被引：1

作者：

Bertin, R

DeMarco, F

Portet, R

机构：

[1] Lab. d'Adaptation Energetique a l'E., Ecole Pratique des Hautes Etudes, F-75006-Paris, 105, Boulevard Raspail

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY | 1996年 / 114卷 / 03期

关键词：

rat; cold adaptation; brown adipose tissue; catecholamines; sympathectomy; adrenal demedullation;

D O I：

10.1016/0300-9629(95)02138-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

1) The aim of this work was to study the effects of surgical denervation of the interscapular brown adipose tissue (IBAT) and of bilateral adrenal demedullation on cold adaptation of rats. 2) After sympathectomy in the 28 degrees C rats, there were substantial decreases in the IBAT NE basal level and turnover rate but no modifications in the heart and adrenals. In the 16 degrees C rats there were also decreases in the basal level and turnover rate of the IBAT NE but, in addition, significant increases in levels and turnover rates of NE in the heart and of epinephrine in the adrenals. 3) Bilateral adrenal demedullation led to increases in the NE basal level and turnover rate in the IBAT and the heart in the 16 degrees C rats; no effects were observed in the 28 degrees C rats. 4) It is concluded that in rats born and reared in a mild cold environment a compensatory stimulation of catecholamine production and turnover rate occurs in some organs after a partial sympathectomy of BAT or bilateral adrenal demedullation.

引用

页码：251 / 256

页数：6

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