The repetitive DNA elements called CRISPRs and their associated genes: Evidence of horizontal transfer among prokaryotes

被引：250

作者：

Godde, James S. ^{[1
]}

Bickerton, Amanda ^{[1
]}

机构：

[1] Monmouth Coll, Dept Biol, Monmouth, IL 61462 USA

来源：

JOURNAL OF MOLECULAR EVOLUTION | 2006年 / 62卷 / 06期

关键词：

repetitive DNA; mobile genetic elements; lateral gene transfer;

D O I：

10.1007/s00239-005-0223-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have found direct DNA repeats 21-47 bp in length interspersed with nonrepetitive sequences of similar length, or clustered regularly interspaced short palindromic repeats (CRISPRs) in a wide range of diverse prokaryotes, including many Archaeal and Eubacterial species. A number of cas, CRISPR-associated genes have also been characterized in many of the same organisms. Phylogenetic analysis of these cas genes suggests that the CRISPR loci have been propagated via HGT, horizontal gene transfer. We suggest a mechanism by which this HGT has occurred, namely, that the CRISPR loci can be carried between cells on megaplasmids >= 40 kb in length.

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收藏

页码：718 / 729

页数：12

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