Arabidopsis Zinc Ribbon 3 is the ortholog of yeast mitochondrial HSP70 escort protein HEP1 and belongs to an ancient protein family in mitochondria and plastids

被引：12

作者：

Kluth, Jantjeline ^{[1
]}

Schmidt, Annika ^{[1
]}

Maerz, Manuela ^{[1
]}

Krupinska, Karin ^{[2
]}

Lorbiecke, Rene ^{[1
]}

机构：

[1] Univ Hamburg, Biozentrum Klein Flottbek & Bot Garten, D-22609 Hamburg, Germany

[2] Univ Kiel, Inst Bot, D-24098 Kiel, Germany

来源：

FEBS LETTERS | 2012年 / 586卷 / 19期

关键词：

Mitochondria; Protein import; Chaperone; HSP; ETCHED1; ZIM17/TIM15; CHAPERONE; THERMOTOLERANCE; DNLZ/HEP; COMPLEX; ZIM17;

D O I：

10.1016/j.febslet.2012.07.052

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

ZR proteins belong to a phylogenetically conserved family of small zinc-ribbon proteins in plastids and mitochondria of higher plants. The function of these proteins is so far unclear. The mitochondrial proteins share sequence similarities with mitochondrial Hsp70 escort proteins (HEP) from Saccharomyces cerevisiae (HEP1) and human. Expression of the mitochondrial ZR protein from Arabidopsis, ZR3, rescued a hep1 knockout mutant from yeast. Accordingly, ZR3 was found to physically interact with mitochondrial Hsp70 from Arabidopsis. Our findings support the idea that mitochondrial and plastidic ZR proteins from higher plants are orthologs of HEP proteins. Structured summary of protein interactions: ZR3 physically interacts with mtHSC70-2 by pull down (View interaction) ZR3 physically interacts with mtHSC70-1 by pull down (View interaction) (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3071 / 3076

页数：6

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