Different impact of hyperhomocysteinemia on cerebral small vessel ischemia and cervico-cerebral atherosclerosis in non-stroke individuals

被引：81

作者：

Park, So-Young ^{[1
]}

An, Se-A ^{[1
]}

Lee, Han-Bin ^{[1
]}

Kim, Yoon ^{[1
]}

Kim, Nam-Keun ^{[2
]}

Kim, Sang-Heum ^{[3
]}

Kim, Ok-Joon ^{[1
]}

Oh, Seung-Hun ^{[1
]}

机构：

[1] CHA Univ, CHA Bundang Med Ctr, Dept Neurol, Songnam, South Korea

[2] CHA Univ, CHA Bundang Med Ctr, Inst Clin Res, Songnam, South Korea

[3] CHA Univ, CHA Bundang Med Ctr, Dept Radiol, Songnam, South Korea

来源：

THROMBOSIS RESEARCH | 2013年 / 131卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Homocysteine; Atherosclerosis; Silent brain infarct; White matter hyperintensity; SILENT BRAIN INFARCTS; WHITE-MATTER LESIONS; CLASSIC RISK-FACTORS; ENDOTHELIAL DYSFUNCTION; PLASMA HOMOCYST(E)INE; NORTHERN MANHATTAN; GENERAL-POPULATION; TOTAL HOMOCYSTEINE; ROTTERDAM SCAN; DISEASE;

D O I：

10.1016/j.thromres.2012.11.011

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background: Our aim was to investigate the impact of plasma total homocysteine (tHcyt) levels on cervico-cerebral atherosclerosis and cerebral small vessel ischemia in non-stroke individuals. Methods: Demographic, laboratory, brain magnetic resonance imaging and magnetic resonance angiographic data were retrospectively analyzed in 682 non-stroke individuals. The association between plasma tHcyt and radiological indices of cervico-cerebral atherosclerosis (any presence of cervico-cerebral [aCC] atherosclerosis, extracranial [EC] atherosclerosis and intracranial [IC] atherosclerosis) and cerebral small vessel ischemia (silent brain infarct [SBI] and cerebral white matter hyperintensity [cWMH]) was analyzed after adjusting for cardiovascular risk factors. Results: There was no association between values for natural log-transformed tHcyt (log-Hcyt) and aCC atherosclerosis, EC atherosclerosis, or IC atherosclerosis. The log-Hcyt was independently associated with cWMH (OR: 3.07, 95% CI: 1.64-5.75) and SBI (OR: 2.91, 95% CI: 1.57-5.40) in multivariate analysis. Median plasma tHcyt level increased as the severity of cWMH increased. Conclusions: Our results suggest that hyperhomocysteinemia plays a major role in the development of cerebral small vessel ischemia, but not in the development of atherosclerosis of major cerebral arteries. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：E12 / E16

页数：5

共 37 条

[1]

Large and small vessels atherosclerosis: Similarities and differences [J].

Aboyans, Victor ;

Lacroix, Philippe ;

Criqui, Michael H. .

PROGRESS IN CARDIOVASCULAR DISEASES, 2007, 50 (02) :112-125

[2]

Inflammatory markers, rather than conventional risk factors, are different between carotid and MCA atherosclerosis [J].

Bang, OY ;

Lee, PH ;

Yoon, SR ;

Lee, MA ;

Joo, IS ;

Huh, K .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2005, 76 (08) :1128-1134

[3]

Homocysteine and risk of ischemic heart disease and stroke -: A meta-analysis [J].

Clarke, R ;

Collins, R ;

Lewington, S ;

Donald, A ;

Alfthan, G ;

Tuomilehto, J ;

Arnesen, E ;

Bonaa, K ;

Blacher, J ;

Boers, GHJ ;

Bostom, A ;

Bots, ML ;

Grobee, DE ;

Brattström, L ;

Breteler, MMB ;

Hofman, A ;

Chambers, JC ;

Kooner, JS ;

Coull, BM ;

Evans, RW ;

Kuller, LH ;

Evers, S ;

Folsom, AR ;

Freyburger, G ;

Parrot, F ;

Genst, J ;

Dalery, K ;

Graham, IM ;

Daly, L ;

Hoogeveen, EK ;

Kostense, PJ ;

Stehouwer, CDA ;

Hopknis, PN ;

Jacques, P ;

Selhub, J ;

Luft, FC ;

Jungers, P ;

Lindgren, A ;

Lolin, YI ;

Loehrer, F ;

Fowler, B ;

Mansoor, MA ;

Malinow, MR ;

Ducimetiere, P ;

Nygard, O ;

Refsum, H ;

Vollset, SE ;

Ueland, PM ;

Omenn, GS ;

Beresford, SAA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (16) :2015-2022

[4]

D'Armiento, FP ;

Bianchi, A ;

de Nigris, F ;

Capuzzi, DM ;

D'Armiento, MR ;

Crimi, G ;

Abete, P ;

Palinski, W ;

Condorelli, M ;

Napoli, C .

STROKE, 2001, 32 (11) :2472-2478

[5]

Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice [J].

Dayal, S ;

Arning, E ;

Bottiglieri, T ;

Böger, RH ;

Sigmund, CD ;

Faraci, FM ;

Lentz, SR .

STROKE, 2004, 35 (08) :1957-1962

[6]

South Asian patients with ischemic stroke - Intracranial large arteries are the predominant site of disease [J].

De Silva, Deidre A. ;

Woon, Fung-Peng ;

Lee, Moi-Pin ;

Chen, Christopher P. L. H. ;

Chang, Hui-Meng ;

Wong, Meng-Cheong .

STROKE, 2007, 38 (09) :2592-2594

[7]

Homocysteine, MTHFR and risk of venous thrombosis:: a meta-analysis of published epidemiological studies [J].

Den Heijer, M ;

Lewington, S ;

Clarke, R .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2005, 3 (02) :292-299

[8]

MR SIGNAL ABNORMALITIES AT 1.5-T IN ALZHEIMER DEMENTIA AND NORMAL AGING [J].

FAZEKAS, F ;

CHAWLUK, JB ;

ALAVI, A ;

HURTIG, HI ;

ZIMMERMAN, RA .

AMERICAN JOURNAL OF ROENTGENOLOGY, 1987, 149 (02) :351-356

[9]

CHINESE-WHITE DIFFERENCES IN THE DISTRIBUTION OF OCCLUSIVE CEREBROVASCULAR-DISEASE [J].

FELDMANN, E ;

DANEAULT, N ;

KWAN, E ;

HO, KJ ;

PESSIN, MS ;

LANGENBERG, P ;

CAPLAN, LR .

NEUROLOGY, 1990, 40 (10) :1541-1545

[10]

ARTERIAL LESIONS UNDERLYING LACUNES [J].

FISHER, CM .

ACTA NEUROPATHOLOGICA, 1969, 12 (01) :1-&

← 1 2 3 4 →