Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains

被引：301

作者：

Markel, P

Shu, P

Ebeling, C

Carlson, GA

Nagle, DL

Smutko, JS

Moore, KJ

机构：

[1] MILLENNIUM PHARMACEUT,CAMBRIDGE,MA 02139

[2] MCLAUGHLIN RES INST,GREAT FALLS,MT 59405

来源：

NATURE GENETICS | 1997年 / 17卷 / 03期

关键词：

D O I：

10.1038/ng1197-280

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Congenic breeding strategies are becoming increasingly important as a greater number of complex trait linkages are identified. Traditionally, the development od a congenic strain Ras been a time-consuming endeavour, requiring ten generations of backcrosses. The recent advent of a dense molecular genetic map of the mouse permits methods that can reduce the time needed for congenic-strain production by 18-24 months. We present a theoretical evaluation of marker-assisted congenic production and provide the empirical data that support it. We present this 'speed congenic' method in a user-friendly manner to encourage other investigators to pursue this or similar methods of congenic production.

引用

页码：280 / 284

页数：5

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