Oxidative downmodulation of the transient K-current IA by intracellular arachidonic acid in rat hippocampal neurons

被引：18

作者：

Bittner, K ^{[1
]}

Müller, W ^{[1
]}

机构：

[1] Inst Physiol Charite, AG Mol Zellphysiol, D-10117 Berlin, Germany

来源：

JOURNAL OF NEUROPHYSIOLOGY | 1999年 / 82卷 / 01期

关键词：

D O I：

10.1152/jn.1999.82.1.508

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Membrane-permeable arachidonic acid (AA) is liberated in a Ca2+-dependent way inside cells. By using whole cell patch clamp we show that intracellular AA (1 pM) selectively reduces I-A in rat hippocampal neurons, whereas extracellular application requires a 10(6)-fold concentration. The nonmetabolized AA analogue ETYA mimics the effect of AA that is blocked by ascorbic acid or intracellular glutathione, suggesting an intracellular oxidative mechanism. We conclude that intracellular AA is extremely potent in reducing I-A by an oxidative mechanism, particularly during oxidative stress.

引用

页码：508 / 511

页数：4

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