Lipase B from Candida antarctica catalyses enantioselective transesterification of 2-(4-methoxybenzyl)-1-cyclohexanols and 2-(4-methoxybenzyl)-1-cyclopentanols

被引：5

作者：

Brunet, C

Zarevucka, M

Wimmer, Z

Legoy, MD

机构：

[1] Univ La Rochelle, Lab Genie Prot & Cellulaire, F-17042 La Rochelle 1, France

[2] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CZ-16610 Prague, Czech Republic

来源：

BIOTECHNOLOGY LETTERS | 1999年 / 21卷 / 07期

关键词：

Candida antarctica; enantioselectivity; transesterification;

D O I：

10.1023/A:1005563617419

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The 2-(4-methoxybenzyl)-1-cyclohexanols and 2-(4-methoxybenzyl)-1-cyclopentanols are the basic structure of a series of juvenile hormone analogs which act as insect growth regulators. Their enantioselective transesterification with the lipase B from Candida antarctica produced pure enantiomers of R-cyclohexyl and R-cyclopentyl acetates (i.e. ee(p) > 99%). Differences observed in the resolution of the four racemic compounds are in accordance with model structure of secondary alcohols suitable for catalysis.

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收藏

页码：605 / 610

页数：6

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