Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future

被引：274

作者：

Geda, Yonas E. ^{[1
,2
]}

Schneider, Lon S. ^{[3
]}

Gitlin, Laura N. ^{[4
]}

Miller, David S. ^{[5
]}

Smith, Gwenn S. ^{[6
]}

Bell, Joanne

Evans, Jovier ^{[7
]}

Lee, Michael ^{[8
,9
]}

Porsteinsson, Anton ^{[10
]}

Lanctot, Krista L. ^{[11
,12
,13
,14
]}

Rosenberg, Paul B. ^{[6
]}

Sultzer, David L. ^{[15
,16
]}

Francis, Paul T. ^{[17
]}

Brodaty, Henry ^{[18
]}

Padala, Prasad P. ^{[19
,20
]}

Onyike, Chiadikaobi U. ^{[6
]}

Ortiz, Luis Agueera ^{[21
,22
]}

Ancoli-Israel, Sonia ^{[23
,24
]}

Bliwise, Donald L. ^{[25
]}

Martin, Jennifer L. ^{[26
,27
]}

Vitiello, Michael V. ^{[28
]}

Yaffe, Kristine ^{[29
]}

Zee, Phyllis C. ^{[30
]}

Herrmann, Nathan

Sweet, Robert A. ^{[31
,32
,33
]}

Ballard, Clive ^{[34
]}

Khin, Ni A. ^{[35
]}

Alfaro, Cara ^{[35
]}

Murray, Patrick S. ^{[33
]}

Schultz, Susan ^{[36
]}

Lyketsos, Constantine G. ^{[6
]}

机构：

[1] Mayo Clin, Coll Med, Dept Psychiat, Scottsdale, AZ USA

[2] Mayo Clin, Coll Med, Dept Neurol, Scottsdale, AZ USA

[3] Univ So Calif, Los Angeles, CA USA

[4] Johns Hopkins Univ, Sch Nursing, Baltimore, MD USA

[5] Bracket, Wayne, PA USA

[6] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Div Geriatr Psychiat & Neuropsychiat, Baltimore, MD 21218 USA

[7] NIMH, Geriatr Res Branch, Geriatr Translat Neurosci & MultiModal Interv Pro, Geriatr Pharmacol Intervent, Bethesda, MD 20892 USA

[8] Univ Minnesota, Inst Translat Neurosci, Dept Neurosci, Minneapolis, MN USA

[9] Univ Minnesota, Inst Translat Neurosci, Ctr Neurodegenerat Dis, Minneapolis, MN USA

[10] Univ Rochester, Sch Med & Dent Rochester, Dept Psychiat, Rochester, NY USA

[11] Sunnybrook Res Inst, Brain Sci Program, Toronto, ON, Canada

[12] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[13] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada

[14] Univ Toronto, Dept Toxicol, Toronto, ON, Canada

[15] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, David Geffen Sch Med, Los Angeles, CA 90024 USA

[16] VA Greater Angeles Healthcare Syst, Psychiat Serv, Los Angeles, CA USA

[17] Kings Coll London, Wolfson Ctr Age Related Dis, London, England

[18] Univ New S Wales, Dementia Collaborat Res Ctr, Sydney, NSW, Australia

[19] Cent Arkansas Vet Healthcare Syst, Geriatr Res Educ & Clin Ctr, Little Rock, AR USA

[20] Univ Arkansas Med Sci, Dept Psychiat, Little Rock, AR 72205 USA

[21] C1BERSAM, Madrid, Spain

[22] Univ Hosp Doce Octubre, Madrid, Spain

[23] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

[24] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[25] Emory Univ, Sch Med, Wesley Woods Hlth Ctr, Dept Neurol, Atlanta, GA USA

[26] Univ Calif Los Angeles, Educ & Clin Ctr, VA Greater Angeles Healthcare Geriatr Res, Los Angeles, CA USA

[27] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[28] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA

[29] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[30] Northwestern Univ, Feinberg Sch Med, Dept Neurol, Chicago, IL 60611 USA

[31] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[32] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

[33] VA Pittsburgh Healthcare Syst, VISN 4 Mental Illness Res Educ & Clin Ctr MIRECC, Pittsburgh, PA USA

[34] Kings Coll London, Wolfson Ctr Age Related Dis, Biomed Res Unit, Inst Psychiat & Alzheimers Soc, London WC2R 2LS, England

[35] US FDA, Ctr Drug Evaluat & Res, Off Drug Evaluat 1 OND, Div Psychiat Prod, Silver Spring, MD USA

[36] Univ Iowa, Carver Coll Med, Dept Psychiat, Iowa City, IA USA

来源：

ALZHEIMERS & DEMENTIA | 2013年 / 9卷 / 05期

关键词：

Neuropsychiatric symptoms; Behavioral and psychological symptoms of dementia; Agitation/aggression; Sleep disorders; Depression; Apathy; Psychosis; Delusions; Hallucinations; Dementia; Alzheimer's disease; Mild cognitive impairment; Mild behavioral impairment; MILD COGNITIVE IMPAIRMENT; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; BEHAVIORAL SYMPTOMS; NATIONAL INSTITUTE; RANDOMIZED-TRIAL; DOUBLE-BLIND; DEPRESSION; DEMENTIA; SCALE;

D O I：

10.1016/j.jalz.2012.12.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS-PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome-specific synthetic reviews and recommendations prepared by NPS-PIA workgroups on depression, apathy, sleep, agitation, and psychosis. (C) 2013 The Alzheimer's Association. All rights reserved.

引用

页码：602 / 608

页数：7

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