NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1

被引：157

作者：

Yaka, R

Thornton, C

Vagts, AJ

Phamluong, K

Bonci, A

Ron, D ^{[1
]}

机构：

[1] Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94110 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 08期

关键词：

D O I：

10.1073/pnas.062046299

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Phosphorylation regulates the function of ligand-gated ion channels such as the N-methyl D-aspartate (NMDA) receptor, Here we report a mechanism for modulation of the phosphorylation state and function of the NMDA receptor via an inhibitory scaffolding protein, RACK1. We found that RACK1 binds both the NR2B subunit of the NMDA receptor and the non receptor protein tyrosine kinase, Fyn. RACK1 inhibits Fyn phosphorylation of NR2B and decreases NMDA receptor-mediated currents in CA1 hippocampal slices. Peptides that disrupt the interactions between RACK1, NR2B, and Fyn induce phosphorylation and potentiate NMDA receptor-mediated currents. Therefore, RACK1 is a regulator of NMDA receptor function and may play a role in synaptic plasticity, addiction, learning, and memory.

引用

页码：5710 / 5715

页数：6

共 30 条

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