Antidepressant-like effects of melatonin in the mouse chronic mild stress model

被引:105
作者
Detanico, Bernardo C. [1 ]
Piato, Angelo L. [1 ,2 ]
Freitas, Jennifer J. [1 ]
Lhullier, Francisco L. [3 ]
Hidalgo, Maria P. [4 ]
Caumo, Wolney [4 ]
Elisabetsky, Elaine [1 ]
机构
[1] Univ Fed Rio Grande do Sul, ICBS, Lab Etnofarmacol, BR-90050170 Porto Alegre, RS, Brazil
[2] Univ Fed Rio Grande do Sul, Fac Farm, Programa Posgrad Ciencias Farmaceut, BR-90610000 Porto Alegre, RS, Brazil
[3] Pontificia Univ Catolica Rio Grande do Sul, Fac Farm, BR-90619000 Porto Alegre, RS, Brazil
[4] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, BR-90035903 Porto Alegre, RS, Brazil
关键词
Melatonin; Depression; Antidepressant; Unpredictable chronic mild stress; HPA axis; Corticosterone; MAJOR DEPRESSIVE DISORDER; PITUITARY-ADRENAL AXIS; RECEPTOR-BINDING-SITES; PSYCHIATRIC-DISORDERS; CIRCADIAN-RHYTHMS; SERUM MELATONIN; ANXIOLYTIC-LIKE; AGOMELATINE; MICE; INVOLVEMENT;
D O I
10.1016/j.ejphar.2009.02.037
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Melatonin is a hormone primarily synthesized by the pineal gland and has been shown to govern seasonal and circadian rhythms, as well as the immune system, certain behaviours, and responses to stress. Chronic exposure to stress is involved in the etiology of human depression, and depressed patients present changes in circadian and seasonal rhythms. This study investigated the effects of daily exogenous melatonin (1 and 10 mg/kg, p.o.) and imipramine (20 mg/kg, i.p.) on the changes in the coat state, grooming behaviour and corticosterone levels induced by the unpredictable chronic mild stress model of depression in mice. As expected, the 5 weeks of unpredictable chronic mild stress schedule induced significant degradation of the coat state, decreased grooming and increased serum corticosterone levels. All of these unpredictable chronic mild stress-induced changes were counteracted by melatonin (P<0.05) and imipramine (P<0.01). Especially in view of the relevance of stress as a major contributing factor in depression, as well as the alleged importance of normalizing a hyperfunctioning HPA axis and resynchronizing circadian rhythms for a successful treatment of depression, this study reassesses the potential of melatonin as an antidepressant. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:121 / 125
页数:5
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