Use of intravenous immunoglobulin in human disease: A review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology

被引：467

作者：

Orange, JS

Hossny, EM

Weiler, CR

Ballow, M

Berger, M

Bonilla, FA

Buckley, R

Chinen, J

El-Gamal, Y

Mazer, BD

Nelson, RP

Patel, DD

Secord, E

Sorensen, RU

Wasserman, RL

Cunningham-Rundles, CC

机构：

[1] Univ Penn, Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

[2] Ain Shams Univ, Dept Pediat, Pediat Allergy & Immunol Unit, Childrens Hosp, Cairo, Egypt

[3] Mayo Clin, Coll Med, Dept Med, Div Allergy, Rochester, MN USA

[4] SUNY Buffalo, Dept Pediat, Sch Med & Biomed Sci, Womens & Childrens Hosp Buffalo, Buffalo, NY 14260 USA

[5] Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA

[6] Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Dept Pathol, Cleveland, OH 44106 USA

[7] Harvard Univ, Sch Med, Dept Pediat, Childrens Hosp Boston, Boston, MA 02115 USA

[8] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA

[9] Duke Univ, Med Ctr, Dept Immunol, Durham, NC USA

[10] NHGRI, NIH, Bethesda, MD 20892 USA

[11] ESPAI, Cairo, Egypt

[12] McGill Univ, Montreal Childrens Hosp, Montreal, PQ H3H 1P3, Canada

[13] McGill Univ, Dept Pediat, Montreal, PQ H3A 2T5, Canada

[14] Indiana Univ, Sch Med, Dept Med, Div Hematol Oncol,Hematol Malignancy Program Immu, Indianapolis, IN 46204 USA

[15] Thursyon Arthritis Res Ctr, Dept Med, Chapel Hill, NC USA

[16] Thursyon Arthritis Res Ctr, Dept Microbiol & Immunol, Chapel Hill, NC USA

[17] Div Rheumatol Allergy & Immunol, Chapel Hill, NC USA

[18] Wayne State Univ, Dept Pediat, Childrens Hosp Michigan, Detroit, MI 48202 USA

[19] Louisiana State Univ, Ctr Hlth Sci, Dept Pediat, New Orleans, LA USA

[20] Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX USA

[21] Mt Sinai Sch Med, Dept Med & Clin Immunol, New York, NY USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2006年 / 117卷 / 04期

关键词：

immunoglobulin; IGIV; intravenous immunoglobulin; transfusion; adverse events; primary immunodeficiency()% immunomodulation; autoimmunity;

D O I：

10.1016/j.jaci.2006.01.015

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Human immunoglobulin prepared for intravenous administration (IGIV) has a number of important uses in the treatment of disease. Some of these are in diseases for which acceptable treatment alternatives do not exist. In this review we have evaluated the evidence underlying a wide variety of IGIV uses and make specific recommendations on the basis of these data. Given the potential risks and inherent scarcity of IGIV, careful consideration of the indications for and administration of IGIV is warranted.

引用

页码：S525 / S553

页数：29

共 363 条

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