Caveolins in vascular smooth muscle: Form organizing function

被引:46
作者
Hardin, CD [1 ]
Vallejo, J
机构
[1] Univ Missouri, Dept Pharmacol & Physiol, Columbia, MO 65212 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Anesthesiol, Los Angeles, CA USA
关键词
D O I
10.1016/j.cardiores.2005.11.024
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Caveolae are becoming increasingly recognized as an important organizational structure for a variety of signal and energy-transducing systems in vascular smooth muscle (VSM). In this review, we discuss the emerging role of the caveolins in organizing and modulating the basic functions of smooth muscle: contraction, growth/proliferation, and the energetic support systems that support these functions. With clear alterations in cell metabolism and function in VSM with altered caveolin-1 (Cav-1) protein expression and with cardiovascular abnormalities associated with Cav-1 null mice, the caveolin family of proteins may play an important role in the function and dysfunction of VSM. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:808 / 815
页数:8
相关论文
共 71 条
  • [1] Na,K-ATPase as a signal transducer
    Aizman, O
    Aperia, A
    [J]. NA,K-ATPASE AND RELATED CATION PUMPS: STRUCTURE, FUNCTION, AND REGULATORY MECHANISMS, 2003, 986 : 489 - 496
  • [2] Store-operated Ca2+-permeable non-selective cation channels in smooth muscle cells
    Albert, AP
    Large, WA
    [J]. CELL CALCIUM, 2003, 33 (5-6) : 345 - 356
  • [3] Coupling of c-Src to large conductance voltage- and Ca2+-activated K+ channels as a new mechanism of agonist-induced vasoconstriction
    Alioua, A
    Mahajan, A
    Nishimaru, K
    Zarei, MM
    Stefani, E
    Toro, L
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (22) : 14560 - 14565
  • [4] Plasticity of TRPC expression in arterial smooth muscle:: correlation with store-operated Ca2+ entry
    Bergdahl, A
    Gomez, MF
    Wihlborg, AK
    Erlinge, D
    Eyjolfson, A
    Xu, SZ
    Beech, DJ
    Dreja, K
    Hellstrand, P
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2005, 288 (04): : C872 - C880
  • [5] Cholesterol depletion impairs vascular reactivity to endothelin-1 by reducing store-operated Ca2+ entry dependent on TRPC1
    Bergdahl, A
    Gomez, MF
    Dreja, K
    Xu, SZ
    Adner, M
    Beech, DJ
    Broman, J
    Hellstrand, P
    Swärd, K
    [J]. CIRCULATION RESEARCH, 2003, 93 (09) : 839 - 847
  • [6] Caveolae-associated signalling in smooth muscle
    Bergdahl, A
    Swärd, K
    [J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2004, 82 (05) : 289 - 299
  • [7] Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Gαq-coupled protein receptors
    Bhatnagar, A
    Sheffler, DJ
    Kroeze, WK
    Compton-Toth, B
    Roth, BL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (33) : 34614 - 34623
  • [8] Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1β-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids
    Bousserouel, S
    Raymondjean, M
    Brouillet, A
    Béréziat, G
    Andréani, M
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 2004, 271 (22): : 4462 - 4473
  • [9] THE NATURE OF FUEL PROVISION FOR THE NA+,K+-ATPASE IN PORCINE VASCULAR SMOOTH-MUSCLE
    CAMPBELL, JD
    PAUL, RJ
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1992, 447 : 67 - 82
  • [10] Urokinase signal transduction and its role in cell migration
    Carlin, SM
    Resink, TJ
    Tamm, M
    Roth, M
    [J]. FASEB JOURNAL, 2005, 19 (02) : 195 - 202