A possible association of Chlamydia pneumoniae infection and acute myocardial infarction in patients younger than 65 years of age

被引:55
作者
Blasi, F
Cosentini, R
Raccanelli, R
Massari, FM
Arosio, C
Tarsia, P
Allegra, L
机构
[1] OSPED MAGGIORE,IRCCS,DEPT CARDIOL,MILAN,ITALY
[2] UNIV MILAN,DEPT EMERGENCY MED,MILAN,ITALY
[3] INST RESP DIS,MILAN,ITALY
关键词
acute myocardial infarction; Chlamydia pneumoniae; polymerase chain reaction; respiratory tract infections;
D O I
10.1378/chest.112.2.309
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Study objectives: We conducted a retrospective study on patients with acute myocardial infarction (AMI) and evaluated the incidence and prevalence of Chlamydia pneumoniae infection. Methods: Sixty-one consecutive patients with AMI aged younger than 65 years were enrolled. Within 24 h of hospital admission, serum samples and pharyngeal swab specimens were obtained from all patients. In 49 of 61 patients, after a mean of 28 days from hospital admission, a second serum sample was drawn. A third serum sample was obtained in 23 of 61 patients. Serologic testing for Chlamydia pneumoniae was performed by a microimmunofluorescence test. We applied a nested-polymerase chain reaction for C pneumoniae DNA detection to pharyngeal swab specimens. Simultaneously, we performed a serologic study for C pneumoniae infection on 61 serum samples obtained from blood donors, matched for age, sex, and smoking habits. Results: Serologic test results for C pneumoniae were consistent with acute reinfection in 12 patients, with chronic infection in 23 patients, and results were negative in 26 patients with AMI. In 3 of 12 patients with acute reinfection pattern and in 3 of 23 patients with chronic infection pattern, C pneumoniae DNA was detected on pharyngeal swab specimens. A significantly higher prevalence of IgG titers was observed ill patients with AMI (35/61) compared to blood donors (18/61) (p=0.003). Conclusion: Our data confirm the possible role of C pneumoniae infection in coronary heart disease and suggest that reinfection may trigger the onset of AMI.
引用
收藏
页码:309 / 312
页数:4
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